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. Author manuscript; available in PMC: 2015 Nov 30.
Published in final edited form as: Cell Rep. 2015 Nov 12;13(8):1658–1669. doi: 10.1016/j.celrep.2015.10.033

Figure 6. Hepatic inactivation of Baf60a protects mice from diet-induced atherosclerosis.

Figure 6

(A) Fed and fasting plasma cholesterol levels in flox/flox:ApoE-/- and BaLKO:ApoE-/- mice fed with WD for 12 weeks (n = 6).

(B) Representative images of en face Oil Red O stained aortic arches.

(C) Quantification of lesion area (n = 10-15).

(D) qPCR analysis of hepatic gene expression in flox/flox:ApoE-/- and BaLKO:ApoE-/- mouse livers (n = 6-9).

(E) Schematic model of the Baf60a/CAR feedforward regulatory loop inmediating diet-induced hypercholesterolemia and atherosclerosis. Data shown inA, C, and D represent mean ± s.e.m.; *P < 0.05 by two-tailed Student's t-test.