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Impaired endothelium-dependent dilations in MCAs of Pparα −/− mice. Contractile response curves to phenylephrine (PE) and dilatory response to ACh and bradykinin on PE- preconstricted middle cerebral artery (MCA) of WT and Pparα −/− mice using isobaric myography. ∗ denotes statistical significance from WT mice (p < 0.05; n = 5 animals). Data are means ± SEM.
