Figure 5.

Elevated superoxide levels in Pparα ^−/− mice are reduced following tempol treatment. Lucigenin- (5 µM) enhanced chemiluminescence in mouse aortic segments from WT and Pparα ^−/− mice after two weeks of treatment with water and tempol. Elevated levels of superoxide in Pparα ^−/− mice were reduced to the level of WT mice after tempol treatment. ∗ denotes statistical significance from water treated WT mice (p < 0.05; n = 3 animals). Data are means ± SEM.