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The diagram shows a novel hypothesis of moyamoya disease development. As pointed out previously, the intimal thickening causes luminal stenosis in the carotid fork. At the same time, however, the carotid fork starts to decrease the outer diameter. These changes gradually progress the disease stage. Both the medial thinning and the waving of elastic lamina may be closely related to the shrinkage of carotid fork. MMD: moyamoya disease.
