Table 2.

Cytotoxic activity of 2 and 6 against both normal Vero Cells and PBMC isolated from healthy volunteers.^a,b

Compound	Test MRSA strains								Vero cells cytotoxicity IC50±SEM (μg/mL)	PBMC cytotoxicity IC50±SEM (μg/mL)
	Therapeutic Index (TI)c
	ATCC 43300	CI 1	CI 2	CI 3	CI 4	CI 5	CI 6	CI 7
2	0.4	0.3	0.4	0.4	0.3	0.2	0.2	0.2	5.7 ± 0.4	46.9 ± 0.8
4	13.5	16.4	13.8	10.9	10.6	13.5	12.1	14.7	1.6 ± 0.4	68.9 ± 0.7
6	6.2	8.1	7.1	7.2	9.9	9.7	6.3	7.2	>100.0	246.8 ± 12.8

^aExperiments were performed in triplicate (N =3).

^bCI = Clinical isolate of methicillin-resistant S. aureus.

^cTI was determined by dividing PBMC cytotoxicity by the inhibitory concentration (IC₅₀) of the drug.