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. Author manuscript; available in PMC: 2016 Nov 15.
Published in final edited form as: Bioorg Med Chem Lett. 2015 Oct 14;25(22):5067–5071. doi: 10.1016/j.bmcl.2015.10.022

Table 3.

Combination index (CIn) values for the equimolar mixture of 2 and 4 in MRSA.a

Test organism CIn values
MRSA (ATCC 43300) 2.0
CIMRSA 1 2.0
CIMRSA 2 2.2
CIMRSA 3 1.7
CIMRSA 4 1.6
CIMRSA 5 1.9
CIMRSA 6 2.2
CIMRSA 7 2.3
a

CIn vales were determined by using the following equation: CIn=([2][2]x)+([4][4]x)+([2]x[4][2]xx[4]x), where [2] and [4] are concentrations of 2 and 4 in combination, inhibiting 50% of cell viability, while [2]x and [4]x are the doses of 2 and 4 alone, respectively, inhibiting 50% of cell viability.