. Author manuscript; available in PMC: 2016 Nov 1.

Published in final edited form as: Mech Dev. 2015 Jun 24;138 Pt 1:43–49. doi: 10.1016/j.mod.2015.06.003

Table 1.

Contribution of different cell type in the neurovascular unit to cerebrovascular development.

Cell type	Released factors	Effect on vascular patterning	References
Pericytes	Ang1	Vessel stabilization	Suri et al., 1996
Astrocytes	VEGF-A	Pro-angiogenic	Stone et al., 1995 Munzenmaier & Harder, 2000 Zhang & Harder, 2002 Potente et al., 2003 Pozzi et al., 2005 West et al., 2005 Li et al., 2013
	EETs
	Shh
	Ang1	Vessel stabilization
Neurons	Ang1	Vessel stabilization	Cao et al., 2004 Joyal et al., 2014
Neurons	VEGF-A	Pro-angiogenic	Cao et al., 2004 Joyal et al., 2014
Microglia	TNFα	Pro-angiogenic	Stefater et al., 2011 Arnold & Betsholtz, 2013 Li et al., 2014
	VEGF-C,D	Pro-/anti-angiogenic
	Wnt5a, Wnt11	Anti-angiogenic

Ang1, angiopoietin-1; EETs, epoxyeicosatrienoic acids; Shh, sonic hedgehog; VEGF, vascular endothelial growth factor; Wnt, wingless integration site.