Table 3.

Heritability of hepatic steatosis and hepatic fibrosis un-adjusted and multivariable-adjusted models and by PNPLA-3 genotype status.

Hepatic steatosis (MRI-PDFF )
	Heritability	95% confidence interval	p-value
Unadjusted	0.87	0.80–0.93	<2.2 x 10−16
Sex + age	0.71	0.57–0.85	<2.2 x 10−16
Sex + age + race	0.52	0.31–0.73	1.1 x 10−11
	SNP % Var	SNP p-value
PNPLA3 genotype (SNP)	2.0%	0.81
Sex + age + SNP	21.0%	0.78
Sex + age + race + SNP	0.03%	0.98

Hepatic fibrosis (MRE Stiffness)
	Heritability	95% confidence interval	p-value
Unadjusted	0.67	0.52–0.83	<2.2 x 10−16
Sex + age	0.51	0.30–0.73	1.8 x 10−11
Sex + age + race	0.50	0.28–0.72	6.1 x 10−11
	SNP % Var	SNP p-value
PNPLA3 genotype (SNP)	1.0%	0.43
Sex + age + SNP	22.0%	0.63
Sex + age + race + SNP	0.0%	0.84

We adjusted the models with PNPLA-3 genotype status to examine the percentage of the each trait is explained by the PNPLA-3 genotype and whether it is a significant association. Addition of PNPLA-3 genotype did not reveal significant association. Hence the percentage contribution of PNPLA-3 genotype on heritability of liver fat and liver fibrosis could be documented. The study was underpowered (n=89) to detect the genotype on trait effect.

Abbreviations: MRI-PDFF, magnetic resonance imaging- proton density fat fraction; MRE, magnetic resonance elastography; PNPLA-3, patatin-like phospholipase domain containing 3