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. Author manuscript; available in PMC: 2016 Dec 1.
Published in final edited form as: Biochim Biophys Acta. 2015 Aug 28;1856(2):211–225. doi: 10.1016/j.bbcan.2015.08.003

Figure 3. Aberrant glycosylation of mucins during cancerous conditions.

Figure 3

Differential glycosylation of mucins occur in malignant conditions that result in truncated glycan structures such as Tn, STn, and T, and several Core 2 extended structures such as sLex and sLea. This aberrant glycosylation is a result of several factors such as altered glycogene expression, mislocalization of glycosyltransferases, abnormal Golgi pH, and the tumor microenvironment.