Differential glycosylation of mucins occur in malignant conditions that result in truncated glycan structures such as Tn, STn, and T, and several Core 2 extended structures such as sLex and sLea. This aberrant glycosylation is a result of several factors such as altered glycogene expression, mislocalization of glycosyltransferases, abnormal Golgi pH, and the tumor microenvironment.