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. Author manuscript; available in PMC: 2016 Dec 4.
Published in final edited form as: J Mol Biol. 2015 Oct 20;427(24):3921–3934. doi: 10.1016/j.jmb.2015.10.003

Figure 4. Influence of D4 on receptor dimerization, and common geometric requirement for Class III RTK dimerization.

Figure 4

(A) Influence of R385A that disrupts D4-D4 homotypic contact on receptor dimerization. D = ligand-induced dimer. M = receptor monomer. (B) PDGFR (left) versus KIT (right) full-length structure. Whereas D1-D3 are different for the two receptors to accommodate different ligands, the D4-D5 homotypic contact is conserved.