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. Author manuscript; available in PMC: 2016 Dec 4.
Published in final edited form as: J Mol Biol. 2015 Oct 20;427(24):3921–3934. doi: 10.1016/j.jmb.2015.10.003

Figure 6. Conformation of TMD-TKD layer.

Figure 6

(A) 2D class average showing features of PDGF-B/PDGFRβ TMD-TKD. (B) EM reconstruction agrees with 2D class average. (C) Fitting of ECD and TMD atomic models. (D) Slice-through view of 3D map. The “funnel” likely represents the linker between ECD and the beginning of TM domain, and the TM helices likely cross each other near their N-terminal portions (near the funnel) and separate at the C-termini in order to connect to the two kinases located on each side of the TKD density. Inset: 2D view.

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