Table 8.
Drugs and corresponding targets.
| Drug | Target | Type |
|---|---|---|
| Aflibercept (AVE0005) | VEGF | Humanize VEGFR-trap |
| AMG 655/Conatumumab | TRAIL-R2 | Monoclonal antibody |
| Apomab | DR5/TRAIL-R2/TNFRSF10B | Monoclonal antibody |
| Axitinib | PDGFR | Tyrosine kinase inhibitor |
| Bendamustine | DNA (SSB and DSB) | Alkylating agent |
| Bevacizumab | VEGF | Monoclonal antibody |
| Carboplatin | DNA | Small molecule inhibitor |
| Cediranib | PDGFR | Tyrosine kinase inhibitor |
| Cediranib | VEGF | Small molecule inhibitor |
| CI-994 | Histone deactylases (HDACs) | Small molecule inhibitor |
| Cisplatin | DNA | Small molecule inhibitor |
| Cixutumumab | IGF-IR | Monoclonal antibody |
| Dalotuzumab | IGF-IR | Monoclonal antibody |
| Docetaxel | Tubulin | Small molecule inhibitor |
| Entinostat | Histone deactylases (HDACs) | Small molecule inhibitor |
| Erlotinib | EGFR | Tyrosine kinase inhibitor |
| Etoposide | Topoisomerase II | Small molecule inhibitor |
| Figitumumab | IGF-IR | Monoclonal antibody |
| Gefitinib | EGFR | Tyrosine kinase inhibitor |
| Ifosfamide | DNA | Alkylating agent |
| Iniparib | PARP-1 | Small molecule inhibitor |
| Ipilimumab | CTLA-4 | Monoclonal antibody |
| Irinotecan | Topoisomerase I | Small molecule inhibitor |
| Linifinib | PDGFR | Tyrosine kinase inhibitor |
| Mapatumumab | DR4/TRAIL-R1 | Monoclonal antibody |
| Medl-4736 | PD-L1 | Monoclonal antibody |
| Motesanib | PDGFR | Tyrosine kinase inhibitor |
| MPDL-3280A | PD-L1 | Monoclonal antibody |
| Nintedanib | VEGFR-1/2/3, PDGFR-α/β, FGFR-1/2/3, Flt-3, Src family | Multiple target Tyrosine kinase inhibitor |
| nivolumab | PD-1 | Monoclonal antibody |
| Olaparib | PARP-1 | Small molecule inhibitor |
| Paclitaxel | Tubulin | Small molecule inhibitor |
| Panobinostat | Histone deactylases (HDACs) | Small molecule inhibitor |
| Pazopanib | VEGFR-1/2/3, PDGFR-α/β, and FGFR-1 and 3 | Multiple target Tyrosine kinase inhibitor |
| Pemetrexed | Thymidylate Synthase | Small molecule inhibitor |
| Pembrolizumab/MK-3475 | PD-1 | Monoclonal antibody |
| Pivanex | Histone deactylases (HDACs) | Small molecule inhibitor |
| Romidepsin (Depsipeptide, FK228) | Histone deactylases (HDACs) | Small molecule inhibitor |
| Sorafenib | VEGFR-2/3, PDGFR-β, c-Kit, Raf, and Flt-3 | Multiple target Tyrosine kinase inhibitor |
| Sunitinib | VEGFR-1/2/3, PDGFR-α/β, c-Kit, Flt-3, and RET | Multiple target Tyrosine kinase inhibitor |
| Talactoferrin | Immune-modulatory function | Glycoprotein, recombinant |
| Topotecan | Topoisomerase I | Small molecule inhibitor |
| Tremelimumab | CTLA-4 | Monoclonal antibody |
| Veliparib | PARP-1 | Small molecule inhibitor |
| Vinblastine | Tubulin | Small molecule inhibitor |
| Vinorelbine | Tubulin | Small molecule inhibitor |
| Vorinostat | Histone deactylases (HDACs) | Small molecule inhibitor |
| YM155/Sepantronium bromide | Survivin | Small molecule inhibitor |