Table 3.
Comparison of 9 serum androgens (ng/mL) across two laboratories.
| GM comparison |
GM current |
Paired t-test p-value |
Spearman’s correlation coefficient |
Deming intercept (95% CI) |
Deming slope (95% CI) |
Bland-Altman bias (95% CI) |
|
|---|---|---|---|---|---|---|---|
|
|
|||||||
| Dehydroepiandrosterone (DHEA)* | 2.82 | 3.19 | <0.01 | 0.99 | 0.19 (0.13, 0.25) | 0.94 (0.90, 0.98) | 0.12 (−0.02, 0.27) |
| Androstenedione (A)* | 1.00 | 1.03 | 0.34 | 0.95 | 0.03 (−0.03, 0.09) | 0.87 (0.78, 0.96) | 0.03 (−0.26, 0.32) |
| Testosterone (T)* | 0.49 | 0.49 | 0.84 | 0.94 | −0.11 (−0.17, −0.06) | 0.86 (0.83, 0.90) | −0.02 (−0.51, 0.47) |
| Dihydrotestosterone (DHT)* | 0.09 | 0.17 | <0.01 | 0.86 | −0.23 (−0.50, 0.03) | 0.61 (0.48, 0.74) | 0.72 (−0.25, 1.69) |
| Androsterone (ADT)* | 0.19 | 0.27 | <0.01 | 0.88 | 0.00 (−0.28, 0.29) | 0.77 (0.60, 0.95) | 0.38 (−0.21, 0.97) |
| Dehydroepiandrosterone sulfate (DHEAS) | 945 | 1043 | <0.01 | 0.96 | 0.20 (−0.16, 0.56) | 0.98 (0.94, 1.03) | 0.10 (−0.12, 0.31) |
| 5α-androstane- 3α,17β diol-3-glucuronide (3α-diol-3G) | 0.99 | 0.79 | 0.01 | 0.88 | −0.22 (−0.40, −0.05) | 1.17 (0.86, 1.49) | −0.22 (−0.89, 0.45) |
| 5α-androstane-3α,17β diol-17-glucuronide (3α-diol-17G) | 1.21 | 1.30 | <0.01 | 0.96 | 0.27 (0.13, 0.41) | 1.10 (0.92, 1.28) | 0.27 (−0.30, 0.84) |
| Androsterone glucuronide (ADT-G) | 26.2 | 48.2 | <0.01 | 0.92 | 0.91 (0.49, 1.33) | 0.91 (0.77, 1.04) | 0.61 (0.09, 1.13) |
GM = Geometric mean
All androgens were natural log-transformed to achieve a normal distribution
*
Androgen measured via GC-MS at comparison laboratory, all others measured via LC-MS/MS.