Table 3.
Number and Percent of Patients with Improvement in Gastroparesis Symptoms over 48 Weeks using Different Definitions of Improvement
| Definition Of Improvement | All Patients (N=262) No. Improve (%) |
Diabetic (DM) (N=85) No. Improve (%) |
Idiopathic (N=177) No. Improve (%) |
P*DM vs Idiopathic |
|---|---|---|---|---|
| No. points decrease from baseline at 48 weeks | ||||
| > 0.00 | 175 (67%) | 52 (61%) | 123 (69%) | .21 |
| 0.25 | 135 (51%) | 38 (45%) | 97 (55%) | .14 |
| 0.50 | 108 (41%) | 34 (40%) | 74 (42%) | .87 |
| 0.75 | 89 (34%) | 25 (29%) | 64 (36%) | .31 |
| 1.00 | 73 (28%) | 21 (25%) | 52 (29%) | .47 |
| 1.25 | 54 (21%) | 17 (20%) | 37 (21%) | .92 |
| 1.50 | 42 (16%) | 13 (15%) | 29 (16%) | .88 |
| 1.75 | 29 (11%) | 11 (13%) | 18 (10%) | .41 |
| 2.00 | 16 (6%) | 6 (7%) | 10 (6%) | .58 |
| % change at 48 weeks | ||||
| 50% over baseline | 38 (15%) | 14 (16%) | 24 (14%) | .56 |
| Mean change: | ||||
| Mean GCSI change | −0.42 ± 1.11 | −0.35 ± 1.18 | −0.46 ± 1.07 | .58 |
*
To compute the difference in mean GCSI change between patients with diabetic gastroparesis and idiopathic, multiple linear regression was used; all other differences between the 2 groups were assessed from multiple logistic models. Each regression model of symptomatic improvement included an indicator variable for the subgroup and controlled for the baseline value of the GCSI score.