Table 1.

Phosphodiesterase inhibitor regulation of alcohol consumption in rodents

Reference	Strain	Behavioral Paradigm	Inhibitor	PDE Target	Alcohol Intake	Sweet Solution
Hu et al. (2011)	C57BL/6J mice	2-bottle choice continuous access to 7–12% (v/v) alcohol vs. water	Rolipram	PDE4b	↓
			Ro-20–1724	PDE4b	↓	N/A
Wen et al. (2012)	Alcohol- preferring Fawn-hooded rats	Operant self-administration of 5% (v/v) alcohol vs. water	Rolipram	PDE4b	↓
		2-bottle choice continuous access to 5% (v/v) alcohol vs. water			↓
		2-bottle choice intermittent access to 10% (v/v) alcohol vs. water			↓	N/A
Bell et al. (2013)	Alcohol- preferring P rats	2-bottle choice 2-h limited access to 15% (v/v) alcohol vs. water (maintenance & relapse)	Ibudilast	Nonspecific; PDE3,4,10,11 preferringc	↓	N/A
	Alcohol- preferring HAD1 rats	2-bottle choice 2-h limited access to 15% (v/v) alcohol vs. water (maintenance & relapse)			↓	N/A
	C57BL/6J mice	Alternating cycles of 2-bottle choice [2-h limited access to 15% (v/v) alcohol vs. water for 5 days, then 2 days off] and chronic ethanol vapor exposure [16-h vapor/day for 4 days, then 3 days abstinence]			↓	N/A
Blednov et al. (2014)	C57BL/6J mice	2-bottle choice continuous access to 15% alcohol vs. water	Propentofylline	Nonspecificd		N/A
			Vinpocetine	PDE1b		N/A
			Milrinone	PDE3b		N/A
			Olprinone	PDE3e		N/A
			CDP840	PDE4f	↓	N/A
			Mesopram	PDE4g	↓	N/A
			Piclamilast	PDE4h	↓	N/A
			Rolipram	PDE4b	↓	N/A
			Zaprinast	PDE5; less potent at PDE1, PDE10, PDE11b		N/A
		limited 3-h 2-bottle choice access to 15% alcohol vs. water	CDP840	PDE4f	↓	N/A
			Mesopram	PDE4g	↓	N/A
			Piclamilast	PDE4h	↓	N/A
			Rolipram	PDE4b	↓	N/A
Logrip et al. (2014)	Wistar rats	operant self-administration of 10% (v/v) naïve and stress history rats	TP-10	PDE10Ai	↓	↓
		operant self-administration of 10% (w/v) alcohol in vapor-dependent and nondependent rats			↓	N/A
	Scr:sP alcohol- preferring rats	operant self-administration of 20% (v/v) alcohol			↓	N/A

^aSucrose or saccharin intake under the same behavioral procedure (self-administration or 2-bottle choice access);

^bBender and Beavo (2006);

^cGibson et al. (2006);

^dMeskini, Némoz, Okyayuz-Baklouti, Lagarde, & Prigent (1994);

^eMizushige, Ueda, Yukiiri, & Suzuki (2002);

^fHughes et al. (1996);

^gDinter et al. (2000);

^hAshton et al. (1994);

ⁱSchmidt et al. (2008)