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. 2015 Sep 15;3(3):220–229. doi: 10.14218/JCTH.2015.00018

Table 1. Interaction between HBV, HDV, and the infected target cell.

Interaction Effect Reference
HDV-HBV interaction
L-HDAg ↔ S-HBsAg HDV assembly 92, 93
S/L-HDAg ↔ HBV enhancers Enh1/2 HBV suppression 97
HDV-interaction with host factors
L-HDAg ↔ DNA dependent RNA-polymerase II HBV suppression 96
L-HDAg ↔ genes of SRE-dependent pathway HBV suppression 95
S/L-HDAg ↔ MxA Induction innate immune responses, HBV suppression 97
HDV ↔ ISGs, signaling genes, cytokines Induction innate immune responses, HBV suppression 107
HBV-interaction with host factors
HBsAg ↔ NFκB, TNF-α, ER-stress pathway Translocation of HDV from nucleus to ER, HDV assembly 94
HBsAg ↔ TLR signaling Suppression TLR signaling 110, 111
HBeAg ↔ TLR2 Impairment innate immune responses 109
HBV ↔ cellular DNA methyltransferases Epigenetic modifications 115, 116
HBx protein ↔ innate signaling pathways Impairment innate immune responses 117
HBV ↔ STAT translocation Impairment IFN signaling 112, 113