Table 2.

Studies evaluating the role of fronto-striatal networks in multiple sclerosis fatigue.

Authors (Year)	Technique	Scales	Population	Outcome
Roelcke et al., 1997	PET	FSS	35 MS	Significant correlation between FSS and glucose reduction in the right DLPFC
Pardini et al., 2010	MRI (DTI)	MFIS	40 RRMS	Significant correlation between MFIS scores and deep left frontal WM, a region found to be involved in fronto-striatal networks, among others
Specogna et al., 2012	fMRI (+single motor task)	FSS	24 RRMS	Significant correlation between FSS scores and activation patterns of the premotor area

DTI, diffusion tensor imaging; FSS, Fatigue Severity Scale; fMRI, functional magnetic reasoning imaging; GM, gray matter; MFIS, Modified Fatigue Impact Scale; MTI, magnetization transfer imaging; PET, Positron Emission Tomography; PMC, premotor cortex; RRMS, relapsing remitting multiple sclerosis; WM, white matter; SMA, supplementary motor area.