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Neutrophil function in cancer is dictated by environmental cues. Neutrophils may be divided into N1 antitumor and N2 protumor cells. TGFβ is a potent driver of the transition from N1 to N2 phenotype whereas IFN-β is a potent driver of the transition in the opposite direction. This exemplifies the notion that neutrophil function in cancer is determined by the chemokine milieu in the microenvironment.
