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. 2015 Nov 16;2015:785783. doi: 10.1155/2015/785783

Figure 5.

Figure 5

AICAR stimulation attenuates HP/HI-induced glucose uptake impairment in HL-1. HL-1 cells were stimulated with HP/HI for 16 h in the presence or absence of AICAR (24 h), and [3H]-deoxyglucose uptake (up) and AKT phosphorylation (down) were assessed in the presence (a) and absence (b) of insulin (200 nmol/L, 10 min). [3H]-deoxyglucose uptake (up) and AKT phosphorylation (down) determination in HL-1 cells stimulated with AICAR (24 h) in the presence and absence of insulin (200 nmol/L, 10 min) (c). Data are expressed as mean ± SD of 4 different experiments performed in duplicate. (∗ P < 0.05, ∗∗∗ P < 0.001 versus control cells without insulin stimulation; &&& P < 0.001 versus control cells stimulated with insulin; # P < 0.05 versus HP/HI-challenged cells stimulated with insulin (a) or without insulin (b); $ P < 0.05 versus AICAR-treated cells stimulated with insulin).