Table 3.
The levels of alpha-fetoprotein and des-gamma-carboxy prothrombin with development of hepatocellular carcinoma in patients with sustained virological response
| Patients with SVR (n = 75) | Non HCC (n = 63) | HCC (n = 12) | P-value1 | |
| AFP levels at pretreatment (ng/mL) | 16.1 ± 20.2 | 17.8 ± 22.2 | 12.6 ± 14.9 | NS |
| AFP levels at the end of IFN treatment (ng/mL) | 13.7 ± 47.8 | 17.9 ± 57.8 | 5.1 ± 1.8 | NS |
| AFP levels at 24 wk after IFN treatment (ng/mL) | 6.7 ± 10.0 | 5.8 ± 4.1 | 8.0 ± 15.1 | NS |
| Pre DCP levels at pretreatment (mAU/mL) | 93.7 ± 374.1 | 131.3 ± 481.4 | 40.3 ± 69.8 | NS |
| Post DCP levels at the end of IFN treatment (mAU/mL) | 140.0 ± 637.9 | 226.9 ± 864.2 | 42.1 ± 83.3 | NS |
| 24 wk DCP levels at 24 wk after IFN treatment (mAU/mL) | 33.9 ± 52.6 | 28.9 ± 37.4 | 39.3 ± 66.5 | NS |
Data are expressed as number (%) or mean ± SD.
1
Comparison between non HCC and HCC. HCC: Hepatocellular carcinoma; AFP: Alpha-fetoprotein; DCP: Des-gamma-carboxy prothrombin; NS: Not significant; SVR: Sustained virological response.