Table 5.
Estimated ORs and 95% CIs for significant (p≤0.05) interactions terms added to multivariable model of GLMM (pooled data)†
| OR | CI 95% | p Value‡ | |
|---|---|---|---|
| Former smoker*discharge diagnosis | |||
| Discharge diagnosis (UA vs NSTEMI) within former smoker (no) | 0.52 | 0.40 to 0.69 | <0.001** |
| Discharge diagnosis (UA vs NSTEMI) within former smoker (yes) | 1.00 | 0.59 to 1.71 | 0.98 |
| Former smoker (yes vs no) within discharge diagnosis (UA) | 2.28 | 1.43 to 3.61 | <0.001** |
| Former smoker (yes vs no) within discharge diagnosis (NSTEMI) | 1.19 | 0.81 to 1.75 | 0.38 |
| Age*previous PCI | |||
| Age (≥75 vs <75 years) within previous PCI (no) | 0.71 | 0.52 to 0.96 | 0.02* |
| Age (≥75 vs <75 years) within previous PCI (yes) | 1.30 | 0.84 to 1.99 | 0.23 |
| Previous PCI (yes vs no) within age (<75 years) | 0.84 | 0.58 to 1.19 | 0.32 |
| Previous PCI (yes vs no) within age (≥75 years) | 1.53 | 1.00 to 2.34 | 0.05* |
| Age*in-hospital heart failure | |||
| Age (≥75 vs <75 years) within in-hospital heart failure (no) | 0.92 | 0.71 to 1.20 | 0.54 |
| Age (≥75 vs <75 years) within in-hospital heart failure (yes) | 0.32 | 0.12 to 0.85 | 0.02* |
| In-hospital heart failure (yes vs no) within age (<75 years) | 0.84 | 0.39 to 1.82 | 0.66 |
| In-hospital heart failure (yes vs no) within age (≥75 years) | 0.29 | 0.14 to 0.57 | <0.001** |
| Age*history of peripheral artery disease | |||
| Age (≥75 vs <75 years) within history of peripheral artery disease (no) | 0.93 | 0.72 to 1.21 | 0.60 |
| Age (≥75 vs <75 years) within history of peripheral artery disease (yes) | 0.34 | 0.14 to 0.80 | 0.01** |
| History of peripheral artery disease (yes vs no) within age (<75 years) | 1.28 | 0.70 to 2.32 | 0.42 |
| History of peripheral artery disease (yes vs no) within age (≥75 years) | 0.47 | 0.24 to 0.91 | 0.02* |
| Age*heart rate | |||
| Age (≥75 vs <75 years) within heart rate (normal) | 0.91 | 0.70 to 1.18 | 0.47 |
| Age (≥75 vs <75 years) within heart rate (tachycardia) | 0.28 | 0.09 to 0.85 | 0.03* |
| Age (≥75 vs <75 years) within heart rate (bradycardia) | 1.25 | 0.31 to 5.00 | 0.75 |
| Heart rate (tachycardia vs normal) within age (<75 years) | 0.67 | 0.34 to 1.30 | 0.23 |
| Heart rate (bradycardia vs normal) within age (<75 years) | 0.81 | 0.33 to 2.01 | 0.65 |
| Heart rate (tachycardia vs normal) within age (≥75 years) | 0.20 | 0.08 to 0.52 | <0.001** |
| Heart rate (bradycardia vs normal) within age (≥75 years) | 1.12 | 0.38 to 3.27 | 0.84 |
*p≤0.05.
**p≤0.01.
†All four ORs per interaction term are presented in the table to form an impression of the nature of the interaction. For instance, two separate ORs for former smoker no versus yes for patients with UA and NSTEMI and two separate ORs for UA versus NSTEMI for former smoker no and yes. These four ORs are all shown, because when interaction between two factors is added to the model, the OR of one factor may depend on the level of the other factor.
‡p Value indicates if OR is significantly different from one.
GLMM, generalised linear mixed model; NSTEMI, non-ST-elevation myocardial infarction; PCI, percutaneous coronary intervention; UA, unstable angina.