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. Author manuscript; available in PMC: 2016 Oct 1.
Published in final edited form as: Curr Top Dev Biol. 2015 Oct 1;115:59–84. doi: 10.1016/bs.ctdb.2015.07.002

Figure 2.

Figure 2

Whole mount oral view of growth and patterning of the developing palatal shelves in mice. Patterns of Shh mRNA expression were detected by whole mount in situ hybridization. R1 – R8 mark the Shh-expressing palatal rugae in the sequence of their formation from E12.5 (A) to E16.5 (F). R1 marks the anterior-posterior boundary (all panels are orientied with the tip of the snout pointing up). The patchy Shh expression in the posterior palatal mark the sensory papilla buds. Scale bar, 500 μm.