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. 2015 Nov 30;5:17549. doi: 10.1038/srep17549

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(A,B) MEF from LSL-Kras^G12D; Nupr1^+/+ and LSL-Kras^G12D; Nupr1^–/– mice were obtained and transduced with an adenovirus expressing the Cre recombinase. Transformation-like images were observed in Nupr1^+/+ cells whereas pictures compatible with senescence were observed in the Nupr1-deficients cells. Values correspond to the percentage of senescent cells. (A) and a strong SA-βGal staining was observed in Nupr1^–/– MEFS whereas no activity was detected in the Nupr1 wild-type cells (B). Tubulin and Ki-67 staining indicates a rearrangement of the cytoskeleton compatible with a senescent phenotype combined with not proliferation in Nupr1-deficients MEFs (C).