Table 3. Reactome pathways with significant enrichment in scarring trachoma: PODA analysis.
| Name | DS | DSp | OR |
|---|---|---|---|
| M Phase | 7.774 | 0.001 | 1.842 |
| Mitotic G2-G2/M phases | 6.935 | 0.001 | 1.649 |
| G2/M Transition | 6.663 | 0.001 | 1.623 |
| G alpha (z) signalling events | 4.803 | 0.001 | 1.525 |
| Golgi Cisternae Pericentriolar Stack Reorganization | 4.146 | 0.001 | 1.239 |
| Proteolytic cleavage of SNARE complex proteins | 3.955 | 0.001 | 1.230 |
| GABA receptor activation | 5.616 | 0.002 | 1.595 |
| Mitotic Prophase | 5.246 | 0.002 | 1.392 |
| Adherens junctions interactions | 4.990 | 0.003 | 1.547 |
| Cell-cell junction organization | 5.100 | 0.004 | 1.641 |
| Synthesis of very long-chain fatty acyl-CoAs | 3.833 | 0.005 | 1.323 |
| Phosphorylation of CD3 and TCR zeta chains | 3.668 | 0.005 | 1.268 |
| G-protein beta:gamma signalling | 4.159 | 0.006 | 1.388 |
| Calmodulin induced events | 4.020 | 0.007 | 1.441 |
| Glucagon signaling in metabolic regulation | 4.266 | 0.007 | 1.425 |
| Loss of Nlp from mitotic centrosomes | 5.181 | 0.011 | 1.551 |
| Loss of proteins required for interphase microtubule organization from the centrosome | 5.181 | 0.011 | 1.551 |
| G beta:gamma signalling through PI3Kgamma | 3.948 | 0.011 | 1.350 |
| Botulinum neurotoxicity | 3.608 | 0.012 | 1.238 |
| Inhibition of Insulin Secretion by Adrenaline/Noradrenaline | 3.689 | 0.013 | 1.332 |
| Synthesis of PIPs at the late endosome membrane | 2.798 | 0.014 | 1.169 |
| Insulin Processing | 3.834 | 0.015 | 1.346 |
| Mitotic Metaphase and Anaphase | 7.029 | 0.018 | 1.760 |
| PLC beta mediated events | 4.205 | 0.024 | 1.541 |
| Mitotic M-M/G1 phases | 7.461 | 0.027 | 1.903 |
| PKA activation in glucagon signalling | 3.243 | 0.031 | 1.322 |
| GPVI-mediated activation cascade | 3.887 | 0.035 | 1.403 |
| Translocation of ZAP-70 to Immunological synapse | 2.631 | 0.035 | 1.177 |
| Assembly of collagen fibrils and other multimeric structures | 4.403 | 0.046 | 1.454 |
| Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components | 3.024 | 0.048 | 1.261 |
| Adenylate cyclase inhibitory pathway | 2.637 | 0.048 | 1.247 |
| Inhibition of adenylate cyclase_pathway | 2.637 | 0.048 | 1.247 |
DS: Discrimination Score. DSp: P value for DS based on 1000 permutations, OR: Odds ratio of being a case, per unit increase in S score.