Table 3. The hydrogen bonds formed between inhibitors and residues^a.

complex	Donor	Acceptor	Distance(Å)	Angle(°)	Frequency(%)b
pDI6W-MDMX	F19′-N-H	Q71-NE1	2.92	135.12	53.34
	W23′-NE1-HE1	M53-OE1	2.88	1490.41	91.72
pDI6W-MDM2	F19′-N-H	Q72-NE1	3.01	138.45	71.64
	W23′-NE1-HE1	L54-OE1	2.87	150.36	99.09
pDIQ-MDMX	F19′-N-H	Q71-NE1	2.90	136.37	58.21
	W23′-NE1-HE1	M53-OE1	2.92	136.82	90.79
pDIQ-MDM2	F19′-N-H	Q72-NE1	2.89	139.51	60.06
	W23′-NE1-HE1	L54-OE1	2.89	148.18	98.96

^aThe hydrogen bonds determined by the acceptor…donor atom distance of less than 3.5 Å and acceptor…H-donor angle of greater than 120 Å,

^bOccupancy (%) is given as the percentage of simulation time that a hydrogen bond exist.