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. 2015 Oct 30;7(11):4404–4420. doi: 10.3390/toxins7114404

Table 1.

Cyanobacterial peptides identified in T. platyurus, A. franciscana (laboratory experiment), blue mussels, and bloom material (environmental samples from the Baltic Sea) and peak areas of their selected transitions in MRM chromatogram recalculated per 100 mg of dry biomass.

m/z [M+H]+ Peptide structure Peak area (counts)
Laboratory experiment Environmental samples
A. franciscana 100 mg d.w. T. platyurus 100 mg d.w. Blue mussels 100 mg d.w. 20 August 2012 Cyanobacteria 100 mg d.w. 27 July 2012
L > 3 cm L < 2 cm
Cyclic peptides: anabaenopeptins, nodularin
AP 918 Phe-CO-[Lys-Val-Hph-MeHty-MetO] 1.1 × 105 0.6 × 105 0.5 × 107 0.7 × 107 0.9 × 107
AP 916 Phe-CO-[Lys-Val-Hty-MeHty-AcSer] - Traces - - 0.3 × 107
AP 902 Phe-CO-[Lys-Val-Hph-MeHty-Met] 0.9 × 105 0.2 × 105 - 0.3 × 107 0.4 × 107
AP 900 Phe-CO-[Lys-Val-Hph-MeHty-AcSer] 1.3 × 105 0.26 × 105 - - 0.5 × 107
AP 884 Ile-CO-[Lys-Val-Hph-MeHty-MetO] 3.2 × 105 1.8 × 105 0.8 × 107 0.9 × 107 1.2 × 107
AP 868 Ile-CO-[Lys-MetO-Hty-MeHty-Met] - Traces 1.7 × 107 1.9 × 107 1.5 × 107
AP 851 (E) Arg-CO-[Lys-Val-Hty-MeAla-Phe] 13.5 × 105 3.8 × 105 1.4 × 107 1.5 × 107 2.1 × 107
AP 837 (B) Arg-CO-[Lys-Val-Hty-MeAla-Phe] - - 0.9 × 107 1.0 × 107 0.5 × 107
AP 828 Phe-CO-[Lys-Val-Hty-MeAla-Phe] 22.9 × 105 5.9 × 105 - 0.9 × 107 1.7 × 107
AP 824 Ile-CO-[Lys-Val-Hph-MeHty-Ser] - - 1.2 × 107 1.4 × 107 5.6 × 107
AP 808 Ile-CO-[Lys-Val-Hty-MeAla-Hph ] - - 1.3 × 107 1.5 × 107 1.5 × 107
NOD 825 Cyclo[MeAsp-Arg-Adda-Glu-Mdhb] 16.0 × 106 1.1 × 106 2.6 × 107 2.8 × 107 5.7 × 107
[Asp]3NOD811 Cyclo[Asp-Arg-Adda-Glu-Mdhb] - - 1.3 × 107 1.5 × 107 3.2 × 107
Linear peptides: spumigins, aeruginosin
SPU 627 Hpla-Hty-MePro-Arg - - - - 0.2 × 107
SPU 613 Hpla-Hty-MePro-Argol - - - - 0.3 × 104
SPU 611 Hpla-Hty-MePro-Argal 7.1 × 106 0.6 × 105 - - 2.5 × 107
SPU 597 Hpla-Hty-Pro-Argal - - - - 0.2 × 104
AER 587 HA-Tyr-Choi-Argal 0.2 × 106 0.1 × 106 - - 1.1 × 107

AER—aeruginosin, AP—anabaenopeptin, NOD—nodularin, SPU—spumigin, HA—hexanoic acid, Hpla—(4-hydroxy-phenyl) lactic acid, Hph—homophenylalanine, Hty—homotyrosine).