Figure 4.

Effect of chronic enteral Fusarium toxin deoxynivalenol (DON) exposure and pre- or post-hepatic E. coli lipopolysaccharide (LPS) infusion on arterial, jugular or portal blood pH in pigs. Reference value: 7.42 in arterial blood [26]. Barrows were either fed a DON contaminated ration (4.59 mg/kg feed) or control feed during 29 days. Infusion groups were divided as follows: pre-hepatic LPS infusion (CON_CON_jugular-LPS_portal, n = 7 and DON_CON_jugular-LPS_portal, n = 6), post-hepatic LPS infusion (CON_LPS_jugular-CON_portal, n = 8 and DON_LPS_jugular-CON_portal, n = 6), and control infusion (CON_CON_jugular-CON_portal, n = 7 and DON_CON_jugular-CON_portal, n = 7). Infusion from time 0 until 60 min with 7.5 µg LPS/kg BW in 0.9% saline. Feed was offered during 15 min prior to infusion start. LSMeans. PSEM = 0.02. Significance: Group (G): p ≤ 0.001; Catheter (C): p ≤ 0.001; Time (T): p ≤ 0.001; G × C × T: p ≤ 0.001. Table illustrates differences between DON and CON fed post-hepatic LPS infused groups at different times. ^T = trend (p ≤ 0.10).

post hoc test (p-value) CON_LPS-CON vs. DON_LPS-CON
time (min)	−30	15	30	45	60	75	90	120	150	180
A. carotis	0.499	0.611	0.327	0.236	0.105	0.105	0.038	0.061 T	0.006	0.623
V. jugularis	0.636	0.585	0.548	0.630	0.268	0.051 T	0.015	0.035	0.047	0.176
V. portae	0.975	0.736	0.637	0.495	0.039	0.132	0.024	0.007	0.002	0.129