Figure 5.

Effect of chronic enteral Fusarium toxin deoxynivalenol (DON) exposure and pre- or post-hepatic E. coli lipopolysaccharide (LPS) infusion on arterial, jugular or portal blood lactate in pigs. Reference: 0.84 ± 0.24 mmol/L in venous blood [28]. Barrows were either fed a DON contaminated ration (4.59 mg/kg feed) or control feed during 29 days. Infusion groups were divided as follows: pre-hepatic LPS infusion (CON_CON_jugular-LPS_portal, n = 7 and DON_CON_jugular-LPS_portal, n = 6), post-hepatic LPS infusion (CON_LPS_jugular-CON_portal, n = 8 and DON_LPS_jugular-CON_portal, n = 6), and control infusion (CON_CON_jugular-CON_portal, n = 7 and DON_CON_jugular-CON_portal, n = 7). Infusion from time 0 until 60 min with 7.5 µg LPS/kg BW in 0.9% saline. Feed was offered during 15 min prior to infusion start. LSMeans. PSEM = 0.56. Significance: Group (G): p ≤ 0.001; Catheter (C): p = 0.78; Time (T): p ≤ 0.001; G × C × T: p ≤ 0.001. Table illustrates differences between DON and CON fed post-hepatic LPS infused groups at different times. ^T = trend (p ≤ 0.10).

post hoc test (p-value) CON_LPS-CON vs. DON_LPS-CON
time (min)	−30	15	30	45	60	75	90	120	150	180
A.carotis	0.912	0.845	0.714	0.969	0.558	0.484	0.161	0.014	0.001	0.999
V.jugularis	0.871	0.993	0.656	0.993	0.775	0.424	0.120	0.004	0.001	0.245
V.portae	0.904	0.838	0.824	0.965	0.911	0.484	0.223	0.004	<0.001	0.252