Figure 6.

Effect of chronic enteral Fusarium toxin deoxynivalenol (DON) exposure and pre- or post-hepatic E. coli lipopolysaccharide (LPS) infusion on arterial, jugular or portal blood bicarbonate (HCO₃⁻) in pigs. Reference range: 20–30 mmol/L in arterial blood [26]. Barrows were either fed a DON contaminated ration (4.59 mg/kg feed) or control feed during 29 days. Infusion groups were divided as follows: pre-hepatic LPS infusion (CON_CON_jugular-LPS_portal, n = 7 and DON_CON_jugular-LPS_portal, n = 6), post-hepatic LPS infusion (CON_LPS_jugular-CON_portal, n = 8 and DON_LPS_jugular-CON_portal, n = 6), and control infusion (CON_CON_jugular-CON_portal, n = 7 and DON_CON_jugular-CON_portal, n = 7). Infusion from time 0 until 60 min with 7.5 µg LPS/kg BW in 0.9% saline. Feed was offered during 15 min prior to infusion start. LSMeans. PSEM = 1.18. Significance: Group (G): p ≤ 0.001; Catheter (C): p ≤ 0.001; Time (T): p ≤ 0.001; G × C × T: p ≤ 0.001. Table illustrates differences between DON and CON fed post-hepatic LPS infused groups at different times,^T = trend (p ≤ 0.10).

post hoc test (p-value) CON_LPS-CON vs. DON_LPS-CON
time (min)	−30	15	30	45	60	75	90	120	150	180
A.carotis	0.639	0.789	0.506	0.443	0.215	0.431	0.153	0.054 T	0.042	0.558
V.jugularis	0.423	0.314	0.835	0.145	0.206	0.327	0.238	0.014	0.012	0.205
V.portae	0.980	0.714	0.408	0.934	0.896	0.202	0.195	0.066 T	0.181	0.539