Figure 7.
Effect of chronic enteral Fusarium toxin deoxynivalenol (DON) exposure and pre- or post-hepatic E. coli lipopolysaccharide (LPS) infusion on arterial, jugular or portal blood base-excess (BE(b)) in pigs. Reference range: −3.5–3.5 mmol/L in arterial blood [26]. Barrows were either fed a DON contaminated ration (4.59 mg/kg feed) or control feed during 29 days. Infusion groups were divided as follows: pre-hepatic LPS infusion (CON_CONjugular-LPSportal, n = 7 and DON_CONjugular-LPSportal, n = 6), post-hepatic LPS infusion (CON_LPSjugular-CONportal, n = 8 and DON_LPSjugular-CONportal, n = 6), and control infusion (CON_CONjugular-CONportal, n = 7 and DON_CONjugular-CONportal, n = 7). Infusion from time 0 until 60 min with 7.5 µg LPS/kg BW in 0.9% saline. Feed was offered during 15 min prior to infusion start. LSMeans. PSEM = 1.18. Significance: Group (G): p ≤ 0.001; Catheter (C): p ≤ 0.001; Time (T): p ≤ 0.001; G × C × T: p ≤ 0.001. Table illustrates differences between DON and CON fed post-hepatic LPS infused groups at different times T = trend (p ≤ 0.10).
| post hoc test (p-value) CON_LPS-CON vs. DON_LPS-CON | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| time (min) | −30 | 15 | 30 | 45 | 60 | 75 | 90 | 120 | 150 | 180 |
| A.carotis | 0.957 | 0.988 | 0.413 | 0.324 | 0.133 | 0.226 | 0.062 T | 0.039 | 0.012 | 0.545 |
| V.jugularis | 0.757 | 0.787 | 0.935 | 0.310 | 0.186 | 0.103 | 0.042 | 0.009 | 0.018 | 0.119 |
| V.portae | 0.931 | 0.941 | 0.364 | 0.566 | 0.268 | 0.099T | 0.064 T | 0.020 | 0.027 | 0.214 |