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Anti HBV activity and cytotoxicity of Compound 1, 2 and entecavir in HepG2.2.15.7 cells.
| Compound | EC50 a (µM) | CC50 b (µM) | Selectivity c Index |
|---|---|---|---|
| Compound 1 | 0.23 ± 0.07 | 4.19 ± 0.12 | 18.2 |
| Compound 2 | 0.80 ± 0.34 | 10.26 ± 3.69 | 12.8 |
| Entecavir | 0.021 ± 0.003 | >100 | >4761 |
a Fifty percent effective concentration based on the inhibition of the HBV viral DNA release; b Fifty percent cytotoxicity concentration based on the reduction of cell viability; c Selectivity index (CC50/EC50).
