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. 2015 Nov 3;21(12):1263–1273. doi: 10.1089/ten.tec.2015.0128

Table 2.

Histological Score23

Nature of predominant tissue
 Hyaline cartilage 4
 Mostly hyaline cartilage 3
 Mixed hyaline and fibrocartilage 2
 Mostly fibrocartilage 1
 Some fibrocartilage, mostly nonchondrocytic cells 0
Structural characteristics
 Surface regularity
  Smooth and intact 3
  Superficial horizontal lamination 2
  Fissures 1
  Severe disruption, including fibrillation 0
 Structural integrity, homogeneity
  Normal 2
  Slight disruption 1
  Severe disintegration, disruptions 0
 Thickness
  100% of adjacent cartilage 2
  50–100% of normal cartilage 1
  0–50% of normal cartilage 0
 Bonding to adjacent cartilage
  Bonded at both ends of graft 2
  Bonded at one end or partially at both ends 1
  Not bonded 1
Freedom from cellular changes of degeneration
 Hypocellularity
  Normal cellularity 2
  Slight hypocellularity 1
  Moderate hypocellularity or hypercellularity 0
 Chondrocyte clustering
  No clusters 2
  <25% of the cells 1
  25–100% of the cells 0
Freedom from degenerative changes in adjacent cartilage
 Normal cellularity, no clusters, normal staining 3
 Normal cellularity, mild clusters, moderate staining 2
 Mild or moderate hypo/hypercellularity, slight staining 1
 Sever hypocellularity, poor or no staining 0
Subchondral bone
 Reconstruction of subchondral bone
  Normal 3
  Reduced subchondral bone reconstruction 2
  Minimal subchondral bone reconstruction 1
  No subchondral bone reconstruction 0
 Inflammatory response in subchondral bone region
  None/mild 2
  Moderate 1
  Severe 0
Safranin-O staining
 Normal or near normal 3
 Moderate 2
 Slight 1
 None 0