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. Author manuscript; available in PMC: 2015 Nov 30.
Published in final edited form as: Future Microbiol. 2015 Sep 7;10:1415–1431. doi: 10.2217/fmb.15.61

Figure 2. High evolvability of costly H526YRif allows its long-term maintenance.

Figure 2

(A) Long-term dynamics, for 30 days (280 generations) of evolution in 15 replicates of a population composed of resistance strain H562YRif and resistance strain H526DRif. Shown are the dynamics for the H526YRif background. The slope of the black line represents the initial difference in fitness between the resistances. (B) Whisker-box shows the relative fitness differences inferred for new beneficial mutations between the two resistant backgrounds, with H526YRif background as a reference. (C) Whisker-box shows the relative differences in time of appearance inferred for new beneficial mutations between the two resistance backgrounds.