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. 2015 Nov 30;5:17407. doi: 10.1038/srep17407

Figure 1. Ba Ameliorates Clinical Symptoms of EAE.

Figure 1

C57BL/6 mice were injected i.p. with PBS (●) or Ba (100 mg/kg, ○) daily (a) at the day of EAE induction, (b) day 10 p.i. (disease onset), (c) day 15 p.i. (disease peak), or (d) during the indicated time points. Results are shown as mean ± SEM (n = 5 each group). (e) Disease distribution at the end points of experiment, and (f) incidence of disease severity at the end points of experiment when treatment started at day 10 p.i. Disease severity is graded as severe (clinical score: > 3), moderate (clinical score: 1.5–3), mild (clinical score: <1.5) or none (no clinical signs). One representative of three independent experiments is shown in a, b, and c. The data in d, e, and f came from three independent experiments when Ba was injected from day 10 p.i. (n = 5–6 each group). **P < 0.01; ***P < 0.001.