Table 3.

Distribution of 1239 Cases of Pneumococcal Meningitis, 1998–2005, According to Serotype Grouping.^*

Serotype	1998–1999 (N = 338)	2000–2001 (N = 333)	2002–2003 (N = 316)	2004–2005 (N = 252)	P Value 2004–2005 vs. 1998–1999
		no. of cases (%)
PCV7 serotypes
All	199 (58.9)	185 (55.6)	105 (33.2)	58 (23.0)	<0.001
4	23 (6.8)	28 (8.4)	15 (4.7)	13 (5.2)	0.49
6B	25 (7.4)	32 (9.6)	14 (4.4)	10 (4.0)	0.11
9V	20 (5.9)	9 (2.7)	9 (2.8)	4 (1.6)	0.01
14	43 (12.7)	35 (10.5)	11 (3.5)	2 (0.8)	<0.001
18C	18 (5.3)	18 (5.4)	19 (6.0)	9 (3.6)	0.43
19F	32 (9.5)	30 (9.0)	14 (4.4)	17 (6.7)	0.29
23F	38 (11.2)	33 (9.9)	23 (7.3)	3 (1.2)	<0.001
PCV7related serotypes
All	43 (12.7)	45 (13.5)	57 (18.0)	30 (11.9)	0.80
6A	23 (6.8)	32 (9.6)	32 (10.1)	14 (5.6)	0.61
9N	6 (1.8)	3 (0.9)	7 (2.2)	5 (2.0)	1.00
23A	6 (1.8)	2 (0.6)	9 (2.8)	7 (2.8)	0.41
Other	8 (2.4)	8 (2.4)	9 (2.8)	4 (1.6)	0.57
NonPCV7 serotypes
All	96 (28.4)	103 (30.9)	154 (48.7)	164 (65.1)	<0.001
3	15 (4.4)	21 (6.3)	19 (6.0)	15 (6.0)	0.45
7F	7 (2.1)	3 (0.9)	6 (1.9)	11 (4.4)	0.15
10A	6 (1.8)	7 (2.1)	3 (0.9)	6 (2.4)	0.77
11A	4 (1.2)	4 (1.2)	15 (4.7)	11 (4.4)	0.02
12F	14 (4.1)	10 (3.0)	9 (2.8)	4 (1.6)	0.09
15A	3 (0.9)	1 (0.3)	5 (1.6)	7 (2.8)	0.11
15B/C	14 (4.1)	13 (3.9)	12 (3.8)	17 (6.7)	0.19
16F	1 (0.3)	6 (1.8)	5 (1.6)	6 (2.4)	0.046
19A	5 (1.5)	7 (2.1)	16 (5.1)	28 (11.1)	<0.001
22F	8 (2.4)	5 (1.5)	20 (6.3)	26 (10.3)	<0.001
33F	1 (0.3)	5 (1.5)	6 (1.9)	5 (2.0)	0.09
35B	3 (0.9)	5 (1.5)	6 (1.9)	9 (3.6)	0.04
35F	4 (1.2)	4 (1.2)	6 (1.9)	2 (0.8)	1.00
38	2 (0.6)	4 (1.2)	6 (1.9)	4 (1.6)	0.41
Other	9 (2.7)	8 (2.4)	20 (6.3)	13 (5.2)	0.13

^*For 1998–2005, 140 isolates lacking serotype or susceptibility data were excluded. P values are two-sided and were calculated with the use of Fisher’s exact test.