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. Author manuscript; available in PMC: 2015 Nov 30.
Published in final edited form as: Circulation. 2012 Mar 28;125(17):2059–2070. doi: 10.1161/CIRCULATIONAHA.111.067306

Figure 5. Spontaneous SR Ca2+-release events (SCaEs) with corresponding inward INCX in myocytes from Ctl and cAF patients.

Figure 5

A, Voltage-clamp protocol (top) and representative recordings of SCaEs (Fluo-3, middle) and corresponding INCX (bottom) from a Ctl (left) and cAF (right) myocyte, respectively following steady-state stimulation for 1-minute at 0.5 Hz. B, Susceptibility to SCaEs in Ctl and cAF. *P<0.05 vs. Ctl (Fisher’s exact test). C, Mean±SEM frequency (left), latency (middle), and amplitude (right) of SCaEs in Ctl and cAF. D, Mean±SEM amplitude of SCaE-generated INCX. C,D, *P<0.05 and **P<0.01 vs. corresponding means in Ctl. Numbers indicate myocytes/patients.