Table 1.
Bone histomorphometric parameters of the femurs of four day old Mitfce/ce mice and corresponding controls
| Mitfce/+ | Mitfce/ce | P value | |
|---|---|---|---|
| Femoral length (mm) | 3.58 ± 0.31 | 3.53 ± 0.44 | 0.879 |
| Femoral distal metaphysis | |||
| Bone volume fraction (BV/TV, %) | 25.84 ± 14.11 | 69.93 ± 17.31 | 0.027 |
| Bone surface density (BS/TV, 1/mm) | 71.13 ± 17.35 | 36.29 ± 8.50 | 0.035 |
| Trabecular number (Tb.N, 1/mm) | 8.42 ± 2.45 | 12.21 ± 1.26 | 0.076 |
| Trabecular thickness (Tb.Th, μm) | 29.47 ±8.28 | 57.37 ± 14.46 | 0.044 |
| Trabecular separation (Tb.Sp, μm) | 97.21 ± 46.33 | 25.07 ± 15.96 | 0.063 |
| Trabecular pattern factor (Tb.Pf) | 17.90 ± 10.94 | 0.59 ± 2.01 | 0.054 |
| Average cortical thickness (Ct.Th, μm) | 79.36 ± 18.06 | 84.76 ± 10.08 | 0.675 |
| Trabecular surface area/total surface area (%) | 31.24 ± 7.08 | 42.72 ± 1.82 | 0.053 |
| Cortical surface area/total surface area (%) | 36.94 ± 4.28 | 32.30 ± 3.22 | 0.208 |
| Trabecular specific bone surface (Tb.BS/Tb.BV, 1/mm) | 71.07± 17.35 | 36.29 ± 8.49 | 0.036 |
| Cortical specific bone surface (Ct.BS/Ct.BV, 1/mm) | 39.66 ± 7.07 | 44.54 ± 6.20 | 0.420 |
| Trabecular volume/total volume (Tb.V/TV, %) | 17.23 ± 9.20 | 49.45 ± 12.43 | 0.023 |
| Marrow volume/total volume (Ma.V/TV, %) | 49.45 ± 9.77 | 21.19± 12.13 | 0.035 |
| Cortical volume/total volume (Ct.V/TV, %) | 33.33 ± 3.56 | 29.35 ± 0.37 | 0.126 |
| Bone mineral density (mg/cc) | |||
| Trabecular bone | 1318.73 ± 23.64 | 1329.19 ± 3.56 | 0.491 |
| Bone marrow | 1078.94 ± 20.14 | 1142.64 ± 25.99 | 0.028 |
| Cortical bone | 1432.96 ± 40.57 | 1419.25 ± 48.65 | 0.727 |
| Cumulative | 1239.05 ± 47.45 | 1314.26 ± 22.12 | 0.068 |
| Femoral diaphysis | |||
| Bone volume fraction (BV/TV, %) | 16.08 ± 12.45 | 38.48± 31.19 | 0.312 |
| Bone surface density (BS/TV, 1/mm) | 93.94 ± 27.33 | 64.59 ± 32.54 | 0.298 |
| Average cortical thickness (Ct.Th, μm) | 82.19 ± 13.37 | 97.75± 11.16 | 0.196 |
| Cortical surface area/total surface area (%) | 47.95 ± 7.75 | 46.25 ± 7.20 | 0.795 |
| Cortical specific bone surface (Ct.BS/Ct.BV, 1/mm) | 35.45 ± 4.91 | 36.21 ± 3.81 | 0.842 |
| Marrow volume/total volume (Ma.V/TV, %) | 44.74 ± 3.89 | 32.07 ± 13.94 | 0.204 |
| Cortical volume/total volume (Ct.V/TV, %) | 46.31 ± 3.64 | 46.12 ± 5.28 | 0.961 |
| Bone mineral density (mg/cc) | |||
| Bone marrow | 1071.97 ± 10.56 | 1091.28 ± 12.55 | 0.111 |
| Cortical bone | 1493.92 ± 52.15 | 1503.64 ± 28.45 | 0.791 |
| Cumulative | 1290.49 ± 21.89 | 1357.81 ± 70.87 | 0.191 |