Figure 6.
In vivo toxicity of KU55933. A) Hair loss in mice treated with radiation (XRT) and free drug (KU) or the nanoparticle formulation of KU55933 (NP KU). The animals were injected with a single dose of 150 μg/Kg of KU and treated with 14 and 16 Gy on the day of the injection. The representative pictures were taken on day 21. B) Skin reaction score on the mice treated with radiation (14 Gy) and KU. The animals were treated as indicated in A) and a score was given based on the work published by Douglas and Fouler (1976).