Skip to main content
. 2015 Oct 12;24(25):7308–7325. doi: 10.1093/hmg/ddv429

Figure 4.

Figure 4.

Immunofluorescence analysis of proteins from Mdivil-treated and untreated WT Htt neurons. (A) Representative images of Mdivi1-treated and untreated WT Htt neurons from mitochondrial dynamics and matrix proteins. (B) Representative images of Mdivi1-treated and untreated WT Htt neurons from synaptic proteins. (C) Quantitative immunofluorescence analysis of mitochondrial dynamics and matrix and synaptic proteins, Drp1, Fis1, Mfn1, Mfn2, Opa1, CypD and synaptophysin, PSD95 and MAP2 of WT Htt neurons treated with Mdivi1 and untreated. In the WT Htt neurons, the levels of both fission and the matrix proteins were significantly decreased, and the fusion protein and the ETC protein were significantly increased when treated with Mdivil at both 25 and 50 μm concentrations.