Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2015 Oct 12;24(25):7308–7325. doi: 10.1093/hmg/ddv429

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author 2015. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com

PMC Copyright notice

Figure 9. — Mitochondrial functional parameters in Mdivil-treated and untreated mutant Htt neurons. Mitochondrial function was assessed by measuring: (A) H₂O₂ production, (B) lipid peroxidation, (C) ATP levels, (D) cell viability and (E) GTPase Drp1 activity. Significantly decreased levels were found in the following parameters in mutant Htt neurons upon Mdivil treatment: H₂O₂ with Mdivil at 25 μm (P = 0.02) and 50 μm (P = 0.01) concentrations, and 4-hydroxy-2-nonenol with Mdivil at 25 μm (P = 0.03) and 50 μm (P = 0.01) concentrations. In contrast, significantly increased levels were found in the following parameters upon Mdivil treatment: ATP production at 25 μm (P = 0.02) and 50 μm (P = 0.04) concentrations, cell viability at 25 μm (P = 0.04) and 50 μm (P = 0.04) concentrations and GTPase Drp1 activity at 25 μm (P = 0.01) and 50 μm (P = 0.04) concentrations.