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. 2015 Oct 13;24(25):7432–7444. doi: 10.1093/hmg/ddv433

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© The Author 2015. Published by Oxford University Press

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — Replication of the association between rs6976 and DNA methylation at cg18099408. (A–C) Plots show the association between genotype at rs6976 and the methylation levels at three CpGs measured by the pyrosequencing assay; (A) the discovery CpG cg18099408, (B) the CpG site located 5 bp downstream of cg18099408 and (C) the CpG site located 9 bp downstream of cg18099408. Data are shown for the 40 OA samples analysed. P-value was calculated using a Kruskal–Wallis test and was Bonferroni-corrected for multiple testing. Horizontal line represents the mean.