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. 2015 Oct 13;24(25):7432–7444. doi: 10.1093/hmg/ddv433

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© The Author 2015. Published by Oxford University Press

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 5. — Replication of the association between rs10948172 and DNA methylation. (A–G) Graphs show the association between genotype at rs10948172 and the methylation levels at seven CpGs measured by pyrosequencing; the four discovery CpGs (B, cg13979708; C, cg19254793; D, cg20913747 and E, cg18551225) and the three additional CpG sites captured by the assays located (A) 3 bp upstream of cg13979708, (F) 7 bp downstream of cg18551225 and (G) 11 bp downstream of cg18551225. Data are shown for the 57 OA samples studied. P-value was calculated using a Kruskal–Wallis test and was Bonferroni-corrected for multiple testing. Horizontal line represents the mean.