Table 3.
Cartilage meQTLs active in non-joint tissues
| Chromosome 3p21.1 | Chromosome 6p21.1 |
Chromosome 15q21.3 | Chromosome 20q11 | ||
|---|---|---|---|---|---|
| GNL3/GLT8D1 |
SUPT3H/RUNX2 |
ALDH1A2 | UQCC/GDF5 | ||
| rs6976 | rs10948172 |
rs3204689 | rs143383 | ||
| cg15147215 | cg19254793 | cg20913747 | cg18551225 | cg12031962 | cg14752227 |
| Pancretic islets (33; r2 = 0.72) | Pancreatic islets (33) | Pancreatic islets (33) | Pancreatic islets (33) | ||
| Lymphocytes (38; r2 = 0.96) | Lymphocytes (38) | Lymphocytes (38; r2 = 0.89) | |||
| Adipose (32; r2 = 0.78) | Adipose (32; r2 = 0.96) | Adipose (32) | Adipose (32; r2 = 0.92) | ||
| Whole blood (32; r2 = 0.96) | Whole blood (32) | Whole blood (32; r2 = 0.92) | |||
| Fibroblasts (39; r2 = 0.96) | Fibroblasts (39; r2 = 0.96) | Fibroblasts (39; r2 = 0.94) | |||
| T lymphocytes (39,40; r2 = 0.96) | T lymphocytes (39,40; r2 = 0.94) | ||||
| Lymphoblastoid (39; r2 = 0.94) | |||||
| Whole blood (31) | |||||
| Lung (41; r2 = 0.92) | Lung (41; r2 = 0.92) | ||||
Whole blood from 247 donors (31). Adipose tissue from 648 donors and peripheral blood from 200 donors (32). Pancreatic islets from 89 donors (33). Lymphocytes from 989 donors with colon cancer and 850 controls (38). Umbilical cord fibroblasts from 107 donors, T-cells from 66 donors and transformed lymphoblastoid cells from 111 donors (39,40). Lung tissue from 210 donors (41). Published meQTL data sets generated using the 450k array were interrogated for the four cartilage meQTLs identified in this study (references are indicated in brackets). If the SNP used in a published report is not the same as that used by us (or is a different SNP, which is not in perfect LD with the OA SNP), then its r2 value relative to the OA SNP is shown.