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. 2015 Nov 30;10(11):e0143680. doi: 10.1371/journal.pone.0143680

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© 2015 Treaster et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Fig 2 — Lysates from each species were pre-stressed for twenty minutes in the noted urea concentrations. Glyceraldehyde 3-phosphate was then added, and the activity of endogenous GAPDH was monitored as ΔA₃₄₀/minute, corresponding to the reduction of NAD⁺ to NADH. Data is reported as the fold change from unstressed activity. Differences among species were assessed by two way analysis of variance indicating a significant main effect of species (F_3,60 = 222.5, p < 0.0001) stress (F_4,60 = 429.9, p < 0.0001), as well as the interaction between species and stress (F_12,60 = 26.1, p < 0.0001). Long-lived species maintain GAPDH function at all doses tested, while shorter-lived species were dramatically compromised. Asterisks indicate significant individual differences as assessed post hoc with Tukey's HSD, p < 0.05 (*), 0.001 (**), and 0.0001(***), respectively. Numbers in parenthesis are maximum species longevity in years.