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. 2015 Nov 30;10(11):e0143416. doi: 10.1371/journal.pone.0143416

Fig 1. Clinical EAN course under dimethyl fumarate treatment.

Fig 1

EAN was induced in Lewis rats by immunisation on day 0 with P2 peptide 53–78 plus CFA. Rats received DMF diluted in 0,08% methylcellulose in tap water at doses of 15 mg/kg, 30mg/kg and 45mg/kg twice daily from day 0 to day 23-post immunisation by oral gavage. Control rats received 0,08% methylcellulose in tap water only. Mean values and SEM are depicted, ROC Area under curve (AUC) 45mg/kg vs. methylcellulose, n = 8 * p<0,05. The experiment was repeated 2 times with similar results.