Fig 7. Dimethyl fumarate induced Nrf2 in axons at the peak of EAN course.

(A) Representative photos of double (merge) Nrf2-NF (neurofilament-axons) staining for sciatic nerve transverse sections of rats (n = 6/group) treated with DMF 15mg/kg, 45mg/kg and methylcellulose, showing Nrf2 positive axons. Scale bar indicates 50μm. (B) Mean numbers of Nrf2 positive axons per mm² sciatic nerve sections as calculated by immunohistochemistry on day 16 p.i. from EAN rats (n = 6/group) receiving orally DMF at different doses (15mg/kg, 45mg/kg/day) and methylcellulose-treated rats. Mean values and SEM are depicted (**p<0,005). The experiment was repeated 2 times with similar results.