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Bead motility reactions using Nck amino acids 61–377 (∆SH3A) WT and 4A mutant. Motility assays were performed using 200 nM N-WASP and 100 nM Nck amino acids 61–377 at 1% NTAD density. WT and the 4A mutant were assayed. Nck was recruited to the membrane by pY3-nephrin. (A) Integrated fluorescence intensity of Alexa488 actin tails. (B) Actin tail length. ***P < 0.001. (C) Alexa568 Nck recruited to the lipid-coated beads at 1% NTAD.
