Fig. 3.

AEDs shift network dynamics from moderate synchrony to states with low synchrony. (A) Combined data from 10 patients and different frequency bands. Left vertical axis: Variability (H) as a function of mean synchronization (R, gray dots). Right vertical axis: Histogram of time (hours) spent at different levels of mean synchronization. Without AEDs (black histogram bars), network dynamics predominantly settles at $\mathrm{R}\simeq 0.5$. With AEDs (blue histogram bars), network dynamics spends more time in low synchrony states. (B) Averages of mean (R, left plot) and variability (H, right plot) of synchronization for hours without (Left) and with (Right) AEDs. *P ≤ 0.05, **P ≤ 0.001, two-sided independent sample t test. (C) Illustration of the behavior of measures R and H as a function of the ratio of excitation and inhibition (E/I) or, more generally, network excitability. The decrease of R and H in our data suggests that AEDs drive the network toward a more disfacilitated/inhibited state (blue arrow).