Fig. 6.

Analysis of loop networks reveals many isolated cliques, consistent with a model in which consecutive loops can form simultaneously by extrusion. Cliques of size three (Left), four (Middle), and five (Right), shown as network representations (Above) and in the Hi-C contact map (Below). Nodes correspond to loop anchor loci; edges and open circles indicate a loop called in (8) (solid green), or using a more relaxed threshold (dashed blue). The five-clique exhibits an additional loop (gray) connecting a clique locus to a locus outside the clique. The loop anchor CTCF motifs are indicated; each middle clique locus contains a pair of CTCF motifs in the divergent orientation.