Skip to main content
. 2015 Nov 9;112(47):14723–14727. doi: 10.1073/pnas.1515228112

Fig. 3.

Fig. 3.

Purinergic receptors in type II afferents. (A) ATP-evoked inward current could be blocked by the P2X antagonist PPADS (red), with partial recovery (blue). (B) UTP (agonist for P2Y2 and P2Y4 receptor) induced inward current in type II afferents. Excitatory postsynaptic currents were recorded, but their frequency was not significantly increased during UTP application. (C) Overlay of responses from a type II afferent when the holding potential was ramped from −90 to +30 mV in normal external solution (black), or after ATP was applied (red). (Inset) Difference current during voltage ramp with and without ATP application. (D) Overlay of responses from a type II afferent when the holding potential was ramped from −110 to +30 mV in normal external solution (black), or after UTP was applied (blue). (Inset) Difference current during voltage ramp with and without UTP application. (E and F) I–V relation of ATP and UTP response revealed by voltage-ramp recordings. The current evoked by ATP reversed at 0 mV (red; n = 3 afferents) and reversal of UTP-evoked current extrapolated to near −70 mV (blue; n = 6 afferents).